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Evidence-based decision-making requires a systematic review and appraisal of the currently available literature. As such, systematic reviews as critical stand-alone research projects inform decisions from various fields, especially in the clinical and public health sectors. Furthermore, as part of grant applications, health sciences publications in high-impact journals, and ethical approvals they do not just improve the chances of acceptance but are often a pre-requisite. This course offers a hands-on introduction to literature search methods for systematic reviews of randomized controlled trials.